Tissue-engineered total disc replacement: final outcomes of a murine caudal disc in vivo study
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چکیده
Consistent with EBSJ's commitment to fostering quality research, we are pleased to feature some of the most highly rated abstracts from the 9th Annual AOSpine North America Fellows Forum in Banff, Canada. Enhancing the quality of evidence in spine care means acknowledging and supporting the efforts of young researchers within our AOSpine North America network. We look forward to seeing more from these promising researchers in the future.
منابع مشابه
Tissue Engineered Disc Replacement. Long term outcome in a rat spinal model
INTRODUCTION Degeneration of the intervertebral discs (IVD) in the human spine is a common and frequent occurrence. It is associated with symptomatic presentations in patients with cervical of lumbar complaints. In the US in excess of 200,000 surgeries per year are performed to either replace the IVD, currently with a mechanical construct, or to fuse the adjacent vertebral bones. Mechanical rep...
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STUDY TYPE Basic science Introduction: Chronic back pain due to degenerative disc disease (DDD) is among the most important medical conditions causing morbidity and significant health care costs. Surgical treatment options include disc replacement or fusion surgery, but are associated with significant short- and long-term risks.1 Biological tissue-engineering of human intervertebral discs (IV...
متن کاملBiological intervertebral disc replacement: an in vivo model and comparison of two surgical techniques to approach the rat caudal disc
STUDY DESIGN Prospective randomized animal study. OBJECTIVE To determine a surgical technique for reproducible and functional intervertebral disc replacement in an orthotopic animal model. METHODS The caudal 3/4 intervertebral disc (IVD) of the rat tail was approached by two surgical techniques: blunt dissection, stripping and retracting (Technique 1) or incising and repairing (Technique 2)...
متن کاملRegenerating nucleus pulposus of the intervertebral disc using biodegradable nanofibrous polymer scaffolds.
Low back pain is a leading health problem in the United States, which is most often resulted from nucleus pulposus (NP) degeneration. To date, the replacement of degenerated NP relies entirely on mechanical devices. However, a biological NP replacement implant is more desirable. Here, we report the regeneration of NP tissue using a biodegradable nanofibrous (NF) scaffold. Rabbit NP cells were s...
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Atsttrin, an engineered molecule composed of three fragments of progranulin(PGRN), exerts comparable anti-inflammation ability. Intervertebral disc degeneration (IDD) is involved in inflammation in which TNF-α plays a key role. This study aims to examine the effect and the mechanism of Atsttrin in the pathogenesis of intervertebral disc degeneration. For this purpose, we took advantage of murin...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2011